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Ifomula yemolekyuli yeZolmitriptan: C16H21N3O2

Chemical IUPAC Igama: (S) -4-({3-[2-(Dimethylamino)ethyl] -1H-indol-5-yl}methyl)-1,3-oxazolidin-2-enye

Inombolo yeCAS: 139264-17-8

Ifomula yoLwakhiwo:

Zolmitriptan

I-Zolmitriptan yinto ekhethiweyo ye-serotonin receptor agonist ye-1B kunye ne-1D subtypes.I-triptan, esetyenziselwa unyango olunzima lokuhlaselwa kwe-migraine kunye okanye ngaphandle kwe-aura kunye neentloko ze-cluster.I-Zolmitriptan yi-synthetic tryptamine derivative kwaye ibonakala njengomgubo omhlophe onyibilikayo ngokuyinxenye emanzini.

I-Zomig yi-serotonin (i-5-HT) i-receptor agonist esetyenziselwa unyango lwe-migraines enzima kubantu abadala.Isithako esisebenzayo kwi-Zomig yi-zolmitriptan, i-agonist ekhethiweyo ye-serotonin receptor.Ihlelwa njenge-triptan, ekukholelwa ukuba iyanciphisa intlungu ye-migraine ngokukhulula ukuvuvukala kunye nokunciphisa imithwalo yegazi.Njengokhetho olukhethiweyo lwe-serotonin receptor agonist, i-Zomig iphinda iyeke iimpawu zentlungu ezithunyelwa kwingqondo kwaye ivimbele ukukhululwa kweekhemikhali ezithile emzimbeni obangela iimpawu ze-migraine, kubandakanywa intlungu yentloko, isicathulo, kunye nokuziva ukukhanya kunye nesandi.I-Zomig iboniswa kwi-migraines kunye okanye ngaphandle kwe-aura, iimpawu ezibonakalayo okanye ezithintekayo abanye abantu abane-migraines bafumana amava phambi kweentlungu zentloko.

Ukusetyenziswa kweZolmitriptan

I-Zolmitriptan isetyenziselwa unyango olunzima lwe-migraines kunye okanye ngaphandle kwe-aura kubantu abadala.I-Zolmitriptan ayijoliswanga kwi-prophylactic therapy ye-migraine okanye ukusetyenziswa kulawulo lwe-hemiplegic okanye i-basilar migraine.

I-Zolmitriptan ifumaneka njenge-tablet eginywayo, i-tablet echithwa ngomlomo, kunye ne-spray ye-nasal, kwi-dose ye-2.5 kunye ne-5 mg.Abantu abafumana i-migraines kwi-aspartame akufanele basebenzise i-tablet echithayo (i-Zomig ZMT), equlethe i-aspartame.

Ngokophononongo lwamavolontiya anempilo, ukutya kubonakala kungenasiphumo esibalulekileyo ekusebenzeni kweZolmitriptan kumadoda nabasetyhini.

I-zolmitriptan e-Zomig ibophelela kwii-receptors ezithile ze-serotonin.Abaphandi bakholelwa ukuba i-Zomig isebenza ngokuzibophelela kwezi zamkeli kwii-neurons (iiseli zemithambo-luvo) nakwimithambo yegazi esengqondweni, nto leyo ebangela ukuba imithambo yegazi ixinzelele kwaye ithintele iikhemikhali ezinokunyusa ukudumba.I-Zomig ikwanciphisa izinto ezibangela intlungu yentloko kwaye ezinokuthi zibandakanyeke kwezinye iimpawu eziqhelekileyo ze-migraine, ezifana ne-nausea, ubuntununtunu ekukhanyeni, kunye nokuvakala kwisandi.I-Zomig isebenza kakuhle xa ithathwa kuphawu lokuqala lwe-migraine.Ayithinteli i-migraine okanye ukunciphisa inani lokuhlaselwa kwe-migraine onayo.

Iziphumo ezibi zeZolmitriptan

Njengawo onke amayeza, iZomig inokubangela iziphumo ebezingalindelekanga.Iziphumo eziqhelekileyo eziqhelekileyo ezifunyanwa ngabantu abathatha iipilisi ze-Zomig ziintlungu, ukuqina okanye uxinzelelo entanyeni, emqaleni, okanye emhlathini;isiyezi, ukubetha, ubuthathaka okanye ukungabi namandla, ukozela, iimvakalelo zokufudumala okanye ukubanda, isicaphucaphu, ukuba buhlungu, nomlomo owomileyo.Ezona ziphumo bezingalindelekanga zixhaphakileyo ezifunyanwa ngabantu abathatha iZomig nasal spray yincasa engaqhelekanga, ukuntyiloza, isiyezi, kunye nobuntununtunu bolusu, ngakumbi ulusu olujikeleze impumlo.

Iimbekiselo

https://en.wikipedia.org/wiki/Zolmitriptan

https://www.ncbi.nlm.nih.gov/pubmed/16412157

https://www.ncbi.nlm.nih.gov/pubmed/18788838

https://www.ncbi.nlm.nih.gov/m/pubmed/10473025

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