Ili ndi gawo la mndandanda wathu womwe ukupitilira kuthandiza ogula kumvetsetsa bwino zopangira zamankhwala.Timamasulira sayansi yamankhwala, kufotokozera za chikhalidwe cha mankhwala, ndikukupatsani uphungu wowona mtima, kotero mutha kusankha mankhwala oyenera a banja lanu!

Molecular formula ya Zolmitriptan: C16H21N3O2

Chemical IUPAC Dzina: (S) -4-({3--[2-(Dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-imodzi

Nambala ya CAS: 139264-17-8

Zomangamanga:

Zolmitriptan

Zolmitriptan ndi kusankha serotonin receptor agonist wa 1B ndi 1D subtypes.Ndi triptan, yomwe imagwiritsidwa ntchito pochiza matenda a migraine kapena opanda aura ndi mutu wamagulu.Zolmitriptan ndi mankhwala opangidwa ndi tryptamine ndipo amawoneka ngati ufa woyera womwe umasungunuka pang'ono m'madzi.

Zomig ndi serotonin (5-HT) receptor agonist yomwe imagwiritsidwa ntchito pochiza mutu waching'alang'ala mwa akulu.Chogwiritsidwa ntchito mu Zomig ndi zolmitriptan, wosankha serotonin receptor agonist.Amatchulidwa ngati triptan, yomwe imakhulupirira kuti imachepetsa ululu wa migraine pochotsa kutupa ndi kuchepetsa mitsempha ya magazi.Monga chosankha cha serotonin receptor agonist, Zomig imayimitsanso zizindikiro zowawa zomwe zimatumizidwa ku ubongo ndikuletsa kutuluka kwa mankhwala ena m'thupi omwe amachititsa zizindikiro za migraine, kuphatikizapo kupweteka kwa mutu, nseru, komanso kumva kuwala ndi phokoso.Zomig imasonyezedwa kwa mutu waching'alang'ala wokhala ndi kapena wopanda aura, zowoneka kapena zomverera zomwe anthu ena omwe ali ndi migraine amakumana nawo mutu usanachitike.

Kugwiritsa ntchito Zolmitriptan

Zolmitriptan amagwiritsidwa ntchito pochiza migraines kapena opanda aura mwa akulu.Zolmitriptan sinapangidwe kuti ikhale yothandiza pochiza mutu waching'alang'ala kapena kuti igwiritsidwe ntchito poyang'anira hemiplegic kapena basilar migraine.

Zolmitriptan imapezeka ngati piritsi yomezedwa, piritsi losokoneza m'kamwa, ndi mphuno yopopera, mu Mlingo wa 2.5 ndi 5 mg.Anthu omwe amadwala mutu waching'alang'ala kuchokera ku aspartame sayenera kugwiritsa ntchito piritsi lowonongeka (Zomig ZMT), lomwe lili ndi aspartame.

Malinga ndi kafukufuku wa anthu odzipereka athanzi, kudya kumawoneka kuti sikukhudza kwambiri mphamvu ya Zolmitriptan mwa amuna ndi akazi.

Zolmitriptan ku Zomig imamangiriza ku ma serotonin receptors ena.Ofufuzawo amakhulupirira kuti Zomig imagwira ntchito pomanga ma receptor awa mu ma neurons (ma cell a minyewa) komanso pamitsempha yamagazi muubongo, zomwe zimapangitsa kuti mitsempha yamagazi igwire ndikuletsa mankhwala omwe amawonjezera kutupa.Zomig imachepetsanso zinthu zomwe zimayambitsa kupweteka kwa mutu komanso zomwe zimatha kukhala ndi zizindikiro zina za mutu waching'alang'ala, monga nseru, kumva kuwala, komanso kumva mawu.Zomig imagwira ntchito bwino ikatengedwa pachizindikiro choyamba cha mutu waching'alang'ala.Sichimalepheretsa mutu waching'alang'ala kapena kuchepetsa chiwerengero cha migraine omwe mumakhala nawo.

Zotsatira za Zolmitriptan

Monga mankhwala onse, Zomig ikhoza kuyambitsa zotsatira zosayembekezereka.Zotsatira zoyipa zomwe anthu amamwa mapiritsi a Zomig ndi zowawa, zomangika kapena kupanikizika pakhosi, mmero, kapena nsagwada;chizungulire, kumva kuwawa, kufooka kapena kusowa mphamvu, kugona, kumva kutentha kapena kuzizira, nseru, kumva kulemera, ndi kuuma pakamwa.Zotsatira zoyipa kwambiri zomwe anthu omwe amatenga Zomig nasal spray ndi kukoma kwachilendo, kunjenjemera, chizungulire, komanso kumva kwa khungu, makamaka khungu lozungulira mphuno.

Maumboni

https://en.wikipedia.org/wiki/Zolmitriptan

https://www.ncbi.nlm.nih.gov/pubmed/16412157

https://www.ncbi.nlm.nih.gov/pubmed/18788838

https://www.ncbi.nlm.nih.gov/m/pubmed/10473025

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